Reaction Details |
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Target | Corticotropin-releasing factor receptor 1 |
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Ligand | BDBM50348793 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_759196 (CHEMBL1811342) |
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Ki | 54±n/a nM |
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Citation | Hodgetts, KJ; Ge, P; Yoon, T; De Lombaert, S; Brodbeck, R; Gulianello, M; Kieltyka, A; Horvath, RF; Kehne, JH; Krause, JE; Maynard, GD; Hoffman, D; Lee, Y; Fung, L; Doller, D Discovery of N-(1-ethylpropyl)-[3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine 59 (NGD 98-2): an orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist. J Med Chem54:4187-206 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Corticotropin-releasing factor receptor 1 |
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Name: | Corticotropin-releasing factor receptor 1 |
Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 |
Type: | Enzyme |
Mol. Mass.: | 50744.31 |
Organism: | Homo sapiens (Human) |
Description: | P34998 |
Residue: | 444 |
Sequence: | MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLR
NIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGC
YLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYI
YQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFF
VNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARV
ARAMSIPTSPTRVSFHSIKQSTAV
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BDBM50348793 |
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n/a |
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Name | BDBM50348793 |
Synonyms: | CHEMBL1807038 |
Type | Small organic molecule |
Emp. Form. | C18H23Cl2N3 |
Mol. Mass. | 352.301 |
SMILES | CCC(CC)Nc1nc(CC)c(nc1C)-c1ccc(Cl)cc1Cl |
Structure |
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