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TargetCorticotropin releasing factor receptor 1
LigandBDBM50132951
Substrate/Competitorn/a
Meas. Tech.ChEMBL_759193
Ki 0.9±n/a nM
Citation Hodgetts KJGe PYoon TDe Lombaert SBrodbeck RGulianello MKieltyka AHorvath RFKehne JHKrause JEMaynard GDHoffman DLee YFung LDoller D Discovery of N-(1-ethylpropyl)-[3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine 59 (NGD 98-2): an orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist. J Med Chem 54:4187-206 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Corticotropin releasing factor receptor 1
Name:Corticotropin releasing factor receptor 1
Synonyms:CRF-R | CRF-R2 Alpha | CRF1 | CRH-R 1 | CRHR1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:Enzyme
Mol. Mass.:50744.31
Organism:Homo sapiens (Human)
Description:P34998
Residue:444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLR
NIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGC
YLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYI
YQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFF
VNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARV
ARAMSIPTSPTRVSFHSIKQSTAV
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  Blast E-value cutoff:
BDBM50132951
n/a
NameBDBM50132951
Synonyms:8-(2,4-dichlorophenyl)-2-methyl-N,N-dipropylquinolin-4-amine | CHEMBL432800 | [8-(2,4-Dichloro-phenyl)-2-methyl-quinolin-4-yl]-dipropyl-amine
TypeSmall organic molecule
Emp. Form.C22H24Cl2N2
Mol. Mass.387.345
SMILESCCCN(CCC)c1cc(C)nc2c(cccc12)-c1ccc(Cl)cc1Cl
Structure
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