| Reaction Details |
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 | Report a problem with these data |
| Target | Peptide deformylase |
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| Ligand | BDBM50089194 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_759155 (CHEMBL1811212) |
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| IC50 | 140±n/a nM |
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| Citation |  Antczak, C; Shum, D; Bassit, B; Frattini, MG; Li, Y; de Stanchina, E; Scheinberg, DA; Djaballah, H Identification of benzofuran-4,5-diones as novel and selective non-hydroxamic acid, non-peptidomimetic based inhibitors of human peptide deformylase. Bioorg Med Chem Lett21:4528-32 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peptide deformylase |
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| Name: | Peptide deformylase |
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| Synonyms: | 3.5.1.88 | BON69_24600 | BON94_18585 | D9G11_24945 | D9G11_25760 | D9J60_20755 | FORC82_p394 | PDF | Polypeptide deformylase | SAMEA3472033_04733 | def | def_2 |
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| Type: | n/a |
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| Mol. Mass.: | 16901.39 |
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| Organism: | Escherichia coli |
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| Description: | n/a |
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| Residue: | 150 |
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| Sequence: | MSVLQVLHIPDERLRKVAKPVEEVNAEIQRIVDDMFETMYAEKGIGLAATQVDIHQRIIV
IDVSENRDERLVLINPELLEKSGETGIEEGCLSIPEQRALVPRAEKVKIRALDRDGKPFE
LEADGLLAICIGLRLGNGKYCTLRLFFNQV
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| BDBM50089194 |
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| n/a |
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| Name | BDBM50089194 |
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| Synonyms: | (R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-pyrrolidine-1-carbonyl)-2-methyl-propyl]-2-pentyl-succinamide | (R)-N4-hydroxy-N1-((S)-1-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)-2-pentylsuccinamide | ACTINONIN | CHEMBL308333 | N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-pyrrolidine-1-carbonyl)-2-methyl-propyl]-2-(R)-pentyl-succinamide | N*4*-Hydroxy-N*1*-[1-(2-hydroxymethyl-pyrrolidine-1-carbonyl)-2-methyl-propyl]-2-pentyl-succinamide |
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| Type | Small organic molecule |
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| Emp. Form. | C19H35N3O5 |
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| Mol. Mass. | 385.4983 |
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| SMILES | CCCCC[C@H](CC(=O)NO)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1CO |
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| Structure | 
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