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TargetActivin receptor type-2B
LigandBDBM50349213
Substrate/Competitorn/a
Meas. Tech.ChEMBL_759695 (CHEMBL1811528)
IC50 10±n/a nM
Citation Stellwagen, JCAdjabeng, GMArnone, MRDickerson, SHHan, CHornberger, KRKing, AJMook, RAPetrov, KGRheault, TRRominger, CMRossanese, OWSmitheman, KNWaterson, AGUehling, DE Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup. Bioorg Med Chem Lett21:4436-40 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Activin receptor type-2B
Name:Activin receptor type-2B
Synonyms:ACVR2B | AVR2B_HUMAN | Activin receptor type-2B
Type:Enzyme Catalytic Domain
Mol. Mass.:57713.76
Organism:Homo sapiens (Human)
Description:gi_116734708
Residue:512
Sequence:
MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCY
ASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAG
GPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHEDPGPPP
PSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMK
HENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSY
LHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVG
TRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQ
HPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSL
IRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI
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  Blast E-value cutoff:
BDBM50349213
n/a
NameBDBM50349213
Synonyms:CHEMBL1808264 | D3RKN_42
TypeSmall organic molecule
Emp. Form.C31H28F3N7O3S2
Mol. Mass.667.724
SMILESCC(C)c1nc(c(s1)-c1ccnc(Nc2ccc(nc2)N2CCOCC2)n1)-c1ccc(F)c(NS(=O)(=O)c2c(F)cccc2F)c1
Structure
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