Reaction Details |
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Target | Activin receptor type-2B |
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Ligand | BDBM50349213 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_759695 (CHEMBL1811528) |
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IC50 | 10±n/a nM |
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Citation | Stellwagen, JC; Adjabeng, GM; Arnone, MR; Dickerson, SH; Han, C; Hornberger, KR; King, AJ; Mook, RA; Petrov, KG; Rheault, TR; Rominger, CM; Rossanese, OW; Smitheman, KN; Waterson, AG; Uehling, DE Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup. Bioorg Med Chem Lett21:4436-40 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Activin receptor type-2B |
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Name: | Activin receptor type-2B |
Synonyms: | ACVR2B | AVR2B_HUMAN | Activin receptor type-2B |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 57713.76 |
Organism: | Homo sapiens (Human) |
Description: | gi_116734708 |
Residue: | 512 |
Sequence: | MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCY
ASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAG
GPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHEDPGPPP
PSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMK
HENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSY
LHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVG
TRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQ
HPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSL
IRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI
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BDBM50349213 |
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n/a |
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Name | BDBM50349213 |
Synonyms: | CHEMBL1808264 | D3RKN_42 |
Type | Small organic molecule |
Emp. Form. | C31H28F3N7O3S2 |
Mol. Mass. | 667.724 |
SMILES | CC(C)c1nc(c(s1)-c1ccnc(Nc2ccc(nc2)N2CCOCC2)n1)-c1ccc(F)c(NS(=O)(=O)c2c(F)cccc2F)c1 |
Structure |
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