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TargetTransmembrane protease serine 11D
LigandBDBM50349340
Substrate/Competitorn/a
Meas. Tech.ChEMBL_760105 (CHEMBL1810428)
Ki 183±n/a nM
Citation Sielaff, FBöttcher-Friebertshäuser, EMeyer, DSaupe, SMVolk, IMGarten, WSteinmetzer, T Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT. Bioorg Med Chem Lett21:4860-4 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Transmembrane protease serine 11D
Name:Transmembrane protease serine 11D
Synonyms:Airway trypsin-like protease | HAT | TM11D_HUMAN | TMPRSS11D | Transmembrane protease serine 11D catalytic chain | Transmembrane protease serine 11D non-catalytic chain
Type:PROTEIN
Mol. Mass.:46272.53
Organism:Homo sapiens (Human)
Description:ChEMBL_840134
Residue:418
Sequence:
MYRPARVTSTSRFLNPYVVCFIVVAGVVILAVTIALLVYFLAFDQKSYFYRSSFQLLNVE
YNSQLNSPATQEYRTLSGRIESLITKTFKESNLRNQFIRAHVAKLRQDGSGVRADVVMKF
QFTRNNNGASMKSRIESVLRQMLNNSGNLEINPSTEITSLTDQAAANWLINECGAGPDLI
TLSEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIA
TSGISTTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAATQNI
PPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGMLCAGVPQGG
VDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWIRQQTGI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50349340
n/a
NameBDBM50349340
Synonyms:CHEMBL1809246
TypeSmall organic molecule
Emp. Form.C28H36N6O6S
Mol. Mass.584.687
SMILESNC(=N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)N2CCOCC2)NS(=O)(=O)Cc2ccccc2)cc1 |r|
Structure
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