| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 2 |
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| Ligand | BDBM7657 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_759530 (CHEMBL1811056) |
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| IC50 | 1±n/a nM |
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| Citation |  Ducray, R; Simpson, I; Jung, FH; Nissink, JW; Kenny, PW; Fitzek, M; Walker, GE; Ward, LT; Hudson, K Discovery of novel imidazo[1,2-a]pyridines as inhibitors of the insulin-like growth factor-1 receptor tyrosine kinase. Bioorg Med Chem Lett21:4698-701 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 2 |
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| Name: | Cyclin-dependent kinase 2 |
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| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33938.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24941 |
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| Residue: | 298 |
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| Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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| BDBM7657 |
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| n/a |
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| Name | BDBM7657 |
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| Synonyms: | 4-[(4-{imidazo[1,2-a]pyridin-3-yl}pyrimidin-2-yl)amino]benzene-1-sulfonamide | CHEMBL73303 | Imidazo[1,2-a]pyridine deriv. 1h |
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| Type | Small organic molecule |
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| Emp. Form. | C17H14N6O2S |
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| Mol. Mass. | 366.397 |
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| SMILES | NS(=O)(=O)c1ccc(Nc2nccc(n2)-c2cnc3ccccn23)cc1 |
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| Structure | 
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