Reaction Details |
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Target | Cannabinoid receptor 2 |
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Ligand | BDBM50350164 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_761451 (CHEMBL1817172) |
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Ki | 220±n/a nM |
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Citation | Pasquini, S; De Rosa, M; Pedani, V; Mugnaini, C; Guida, F; Luongo, L; De Chiaro, M; Maione, S; Dragoni, S; Frosini, M; Ligresti, A; Di Marzo, V; Corelli, F Investigations on the 4-quinolone-3-carboxylic acid motif. 4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice. J Med Chem54:5444-53 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cannabinoid receptor 2 |
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Name: | Cannabinoid receptor 2 |
Synonyms: | CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 39690.94 |
Organism: | Homo sapiens (Human) |
Description: | P34972 |
Residue: | 360 |
Sequence: | MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILS
SHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTAS
VGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCS
ELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLD
VRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYA
LRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
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BDBM50350164 |
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n/a |
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Name | BDBM50350164 |
Synonyms: | CHEMBL1814471 |
Type | Small organic molecule |
Emp. Form. | C26H26N2O2 |
Mol. Mass. | 398.4968 |
SMILES | Oc1c(cnc2c(cccc12)-c1ccccc1)C(=O)NC12CC3CC(CC(C3)C1)C2 |TLB:19:20:23.22.27:25,THB:21:22:25:29.20.28,21:20:23.22.27:25,28:20:23:27.26.25,28:26:23:29.21.20| |
Structure |
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