Reaction Details |
| Report a problem with these data |
Target | Dipeptidyl peptidase 8 |
---|
Ligand | BDBM50350172 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_761368 (CHEMBL1816906) |
---|
IC50 | 32±n/a nM |
---|
Citation | Van Goethem, S; Matheeussen, V; Joossens, J; Lambeir, AM; Chen, X; De Meester, I; Haemers, A; Augustyns, K; Van der Veken, P Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal? J Med Chem54:5737-46 (2011) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Dipeptidyl peptidase 8 |
---|
Name: | Dipeptidyl peptidase 8 |
Synonyms: | DPP8 | DPP8_HUMAN | DPRP-1 | DPRP1 | Dipeptidyl peptidase 8 (DPP-8) | Dipeptidyl peptidase 8 (DPP8) | Dipeptidyl peptidase 8/9 | Dipeptidyl peptidase IV-related protein 1 | Dipeptidyl peptidase VIII | Dipeptidyl peptidase VIII (DDP-VIII) | Prolyl dipeptidase DPP8 |
Type: | Enzyme |
Mol. Mass.: | 103342.62 |
Organism: | Homo sapiens (Human) |
Description: | Q6V1X1 |
Residue: | 898 |
Sequence: | MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQ
LKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPK
TINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLF
QAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISN
IVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILR
ILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVI
DKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVM
ERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLY
KITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYF
EGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLY
KLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGK
KYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKY
KMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAP
VTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAH
TSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI
|
|
|
BDBM50350172 |
---|
n/a |
---|
Name | BDBM50350172 |
Synonyms: | CHEMBL1814748 |
Type | Small organic molecule |
Emp. Form. | C30H32F2N4O2 |
Mol. Mass. | 518.5975 |
SMILES | C[C@H]1CN(CCN1C(c1ccc(F)cc1)c1ccc(F)cc1)C(=O)C[C@H](N)C(=O)N1Cc2ccccc2C1 |r| |
Structure |
|