Reaction Details |
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Target | Polyunsaturated fatty acid lipoxygenase ALOX12 |
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Ligand | BDBM50350394 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_761399 (CHEMBL1817029) |
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Ki | 700±n/a nM |
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Citation | Kenyon, V; Rai, G; Jadhav, A; Schultz, L; Armstrong, M; Jameson, JB; Perry, S; Joshi, N; Bougie, JM; Leister, W; Taylor-Fishwick, DA; Nadler, JL; Holinstat, M; Simeonov, A; Maloney, DJ; Holman, TR Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase. J Med Chem54:5485-97 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Polyunsaturated fatty acid lipoxygenase ALOX12 |
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Name: | Polyunsaturated fatty acid lipoxygenase ALOX12 |
Synonyms: | 12-LOX | 12-Lipoxygenase (12-LOX) | 12LO | ALOX12 | Arachidonate 12-lipoxygenase | Arachidonate 12-lipoxygenase, 12S-type | LOG12 | LOX12_HUMAN | Platelet 12-lipoxygenase | Platelet-type lipoxygenase 12 |
Type: | Protein |
Mol. Mass.: | 75689.18 |
Organism: | Homo sapiens (Human) |
Description: | P18054 |
Residue: | 663 |
Sequence: | MGRYRIRVATGAWLFSGSYNRVQLWLVGTRGEAELELQLRPARGEEEEFDHDVAEDLGLL
QFVRLRKHHWLVDDAWFCDRITVQGPGACAEVAFPCYRWVQGEDILSLPEGTARLPGDNA
LDMFQKHREKELKDRQQIYCWATWKEGLPLTIAADRKDDLPPNMRFHEEKRLDFEWTLKA
GALEMALKRVYTLLSSWNCLEDFDQIFWGQKSALAEKVRQCWQDDELFSYQFLNGANPML
LRRSTSLPSRLVLPSGMEELQAQLEKELQNGSLFEADFILLDGIPANVIRGEKQYLAAPL
VMLKMEPNGKLQPMVIQIQPPNPSSPTPTLFLPSDPPLAWLLAKSWVRNSDFQLHEIQYH
LLNTHLVAEVIAVATMRCLPGLHPIFKFLIPHIRYTMEINTRARTQLISDGGIFDKAVST
GGGGHVQLLRRAAAQLTYCSLCPPDDLADRGLLGLPGALYAHDALRLWEIIARYVEGIVH
LFYQRDDIVKGDPELQAWCREITEVGLCQAQDRGFPVSFQSQSQLCHFLTMCVFTCTAQH
AAINQGQLDWYAWVPNAPCTMRMPPPTTKEDVTMATVMGSLPDVRQACLQMAISWHLSRR
QPDMVPLGHHKEKYFSGPKPKAVLNQFRTDLEKLEKEITARNEQLDWPYEYLKPSCIENS
VTI
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BDBM50350394 |
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n/a |
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Name | BDBM50350394 |
Synonyms: | CHEMBL528045 |
Type | Small organic molecule |
Emp. Form. | C16H13ClN2O2S |
Mol. Mass. | 332.805 |
SMILES | CC(=O)NC(c1cccs1)c1cc(Cl)c2cccnc2c1O |
Structure |
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