| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Polyunsaturated fatty acid lipoxygenase ALOX15 |
|---|
| Ligand | BDBM50009001 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_761391 (CHEMBL1817021) |
|---|
| Ki | 600±n/a nM |
|---|
| Citation |  Kenyon, V; Rai, G; Jadhav, A; Schultz, L; Armstrong, M; Jameson, JB; Perry, S; Joshi, N; Bougie, JM; Leister, W; Taylor-Fishwick, DA; Nadler, JL; Holinstat, M; Simeonov, A; Maloney, DJ; Holman, TR Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase. J Med Chem54:5485-97 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Polyunsaturated fatty acid lipoxygenase ALOX15 |
|---|
| Name: | Polyunsaturated fatty acid lipoxygenase ALOX15 |
|---|
| Synonyms: | 15-Lipoxygenase-1 (15-LOX-1) | ALOX15 | Arachidonate 15-lipoxygenase | Arachidonate 15-lipoxygenase-1 | LOG15 | LOX15_HUMAN | Reticulocyte 15-lipoxygenase-1 | Sphingosine 1-phosphate receptor 1 (S1P1) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 74804.05 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 662 |
|---|
| Sequence: | MGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPL
LFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDP
QGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVSLAK
GLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVV
LRRSAHLPARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPL
VMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQSH
LLRGHLMAEVIVVATMRCLPSIHPIFKLIIPHLRYTLEINVRARTGLVSDMGIFDQIMST
GGGGHVQLLKQAGAFLTYSSFCPPDDLADRGLLGVKSSFYAQDALRLWEIIYRYVEGIVS
LHYKTDVAVKDDPELQTWCREITEIGLQGAQDRGFPVSLQARDQVCHFVTMCIFTCTGQH
ASVHLGQLDWYSWVPNAPCTMRLPPPTTKDATLETVMATLPNFHQASLQMSITWQLGRRQ
PVMVAVGQHEEEYFSGPEPKAVLKKFREELAALDKEIEIRNAKLDMPYEYLRPSVVENSV
AI
|
|
|
|---|
| BDBM50009001 |
|---|
| n/a |
|---|
| Name | BDBM50009001 |
|---|
| Synonyms: | 5,6,7-Trihydroxyflavone | 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one | Baicalein | Baicalein, 14 | Baicalein, 8 | CHEMBL8260 | US10252984, Table 2.33 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H10O5 |
|---|
| Mol. Mass. | 270.2369 |
|---|
| SMILES | Oc1cc2oc(cc(=O)c2c(O)c1O)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
