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TargetPolyunsaturated fatty acid lipoxygenase ALOX15B
LigandBDBM65361
Substrate/Competitorn/a
Meas. Tech.ChEMBL_761396 (CHEMBL1817026)
IC50>100000±n/a nM
Citation Kenyon, VRai, GJadhav, ASchultz, LArmstrong, MJameson, JBPerry, SJoshi, NBougie, JMLeister, WTaylor-Fishwick, DANadler, JLHolinstat, MSimeonov, AMaloney, DJHolman, TR Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase. J Med Chem54:5485-97 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Polyunsaturated fatty acid lipoxygenase ALOX15B
Name:Polyunsaturated fatty acid lipoxygenase ALOX15B
Synonyms:15-LOX-2 | 15-Lipo-oxygenase type 2 (15-LOX-2) | 15-Lipoxygenase-2 (15-LOX-2) | 15-lipoxygenase 2 | ALOX15B | Arachidonate 15-lipoxygenase type II | Arachidonate 15-lipoxygenase, type II | Arachidonate 15-lipoxygenase-2 | Epithelial 15-lipoxygenase-2 | LX15B_HUMAN
Type:Protein
Mol. Mass.:75850.40
Organism:Homo sapiens (Human)
Description:n/a
Residue:676
Sequence:
MAEFRVRVSTGEAFGAGTWDKVSVSIVGTRGESPPLPLDNLGKEFTAGAEEDFQVTLPED
VGRVLLLRVHKAPPVLPLLGPLAPDAWFCRWFQLTPPRGGHLLFPCYQWLEGAGTLVLQE
GTAKVSWADHHPVLQQQRQEELQARQEMYQWKAYNPGWPHCLDEKTVEDLELNIKYSTAK
NANFYLQAGSAFAEMKIKGLLDRKGLWRSLNEMKRIFNFRRTPAAEHAFEHWQEDAFFAS
QFLNGLNPVLIRRCHYLPKNFPVTDAMVASVLGPGTSLQAELEKGSLFLVDHGILSGIQT
NVINGKPQFSAAPMTLLYQSPGCGPLLPLAIQLSQTPGPNSPIFLPTDDKWDWLLAKTWV
RNAEFSFHEALTHLLHSHLLPEVFTLATLRQLPHCHPLFKLLIPHTRYTLHINTLARELL
IVPGQVVDRSTGIGIEGFSELIQRNMKQLNYSLLCLPEDIRTRGVEDIPGYYYRDDGMQI
WGAVERFVSEIIGIYYPSDESVQDDRELQAWVREIFSKGFLNQESSGIPSSLETREALVQ
YVTMVIFTCSAKHAAVSAGQFDSCAWMPNLPPSMQLPPPTSKGLATCEGFIATLPPVNAT
CDVILALWLLSKEPGDQRPLGTYPDEHFTEEAPRRSIATFQSRLAQISRGIQERNQGLVL
PYTYLDPPLIENSVSI
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  Blast E-value cutoff:
BDBM65361
n/a
NameBDBM65361
Synonyms:MLS000714362 | N-[(8-hydroxy-7-quinolinyl)-thiophen-2-ylmethyl]propanamide | N-[(8-hydroxy-7-quinolyl)-(2-thienyl)methyl]propionamide | N-[(8-hydroxyquinolin-7-yl)-thiophen-2-ylmethyl]propanamide | N-[(8-oxidanylquinolin-7-yl)-thiophen-2-yl-methyl]propanamide | SMR000274342 | cid_3136123
TypeSmall organic molecule
Emp. Form.C17H16N2O2S
Mol. Mass.312.386
SMILESCCC(=O)NC(c1cccs1)c1ccc2cccnc2c1O
Structure
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