| Reaction Details |
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 | Report a problem with these data |
| Target | Quinolone resistance protein NorA |
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| Ligand | BDBM50350505 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_762633 (CHEMBL1817278) |
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| IC50 | 7000±n/a nM |
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| Citation |  Sabatini, S; Gosetto, F; Manfroni, G; Tabarrini, O; Kaatz, GW; Patel, D; Cecchetti, V Evolution from a natural flavones nucleus to obtain 2-(4-Propoxyphenyl)quinoline derivatives as potent inhibitors of the S. aureus NorA efflux pump. J Med Chem54:5722-36 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Quinolone resistance protein NorA |
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| Name: | Quinolone resistance protein NorA |
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| Synonyms: | NORA_STAAU | norA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42273.03 |
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| Organism: | Staphylococcus aureus |
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| Description: | ChEMBL_961221 |
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| Residue: | 388 |
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| Sequence: | MNKQIFVLYFNIFLIFLGIGLVIPVLPVYLKDLGLTGSDLGLLVAAFALSQMIISPFGGT
LADKLGKKLIICIGLILFSVSEFMFAVGHNFSVLMLSRVIGGMSAGMVMPGVTGLIADIS
PSHQKAKNFGYMSAIINSGFILGPGIGGFMAEVSHRMPFYFAGALGILAFIMSIVLIHDP
KKSTTSGFQKLEPQLLTKINWKVFITPVILTLVLSFGLSAFETLYSLYTADKVNYSPKDI
SIAITGGGIFGALFQIYFFDKFMKYFSELTFIAWSLLYSVVVLILLVFANGYWSIMLISF
VVFIGFDMIRPAITNYFSNIAGERQGFAGGLNSTFTSMGNFIGPLIAGALFDVHIEAPIY
MAIGVSLAGVVIVLIEKQHRAKLKEQNM
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| BDBM50350505 |
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| n/a |
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| Name | BDBM50350505 |
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| Synonyms: | CHEMBL1651180 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H30N2O2 |
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| Mol. Mass. | 378.5072 |
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| SMILES | CCCOc1ccc(cc1)-c1cc(OCCN(CC)CC)c2ccccc2n1 |
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| Structure | 
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