| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glycogen phosphorylase, muscle form |
|---|
| Ligand | BDBM50350688 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_762684 (CHEMBL1817502) |
|---|
| IC50 | 3200±n/a nM |
|---|
| Citation |  Habash, M; Taha, MO Ligand-based modelling followed by synthetic exploration unveil novel glycogen phosphorylase inhibitory leads. Bioorg Med Chem19:4746-71 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glycogen phosphorylase, muscle form |
|---|
| Name: | Glycogen phosphorylase, muscle form |
|---|
| Synonyms: | Glycogen Phosphorylase (PYGM) | Glycogen phosphorylase a (RMGPa) | Glycogen phosphorylase, muscle form | Myophosphorylase | PYGM | PYGM_RABIT |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 97296.32 |
|---|
| Organism: | Oryctolagus cuniculus (rabbit) |
|---|
| Description: | Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A. |
|---|
| Residue: | 843 |
|---|
| Sequence: | MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTV
RDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDM
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKICGGWQMEEA
DDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVN
TMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRVLVDLERL
DWDKAWEVTVKTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFP
GDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKF
QNKTNGITPRRWLVLCNPGLAEIIAERIGEEYISDLDQLRKLLSYVDDEAFIRDVAKVKQ
ENKLKFAAYLEREYKVHINPNSLFDVQVKRIHEYKRQLLNCLHVITLYNRIKKEPNKFVV
PRTVMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPVVGDRLRVIFLENYRVSLAEKVIPA
ADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVD
RLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEE
YVKCQERVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDE
KIP
|
|
|
|---|
| BDBM50350688 |
|---|
| n/a |
|---|
| Name | BDBM50350688 |
|---|
| Synonyms: | CHEMBL1814498 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H11ClN2O |
|---|
| Mol. Mass. | 306.746 |
|---|
| SMILES | Clc1cccc(c1)-c1nnc(o1)-c1ccc2ccccc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
