Reaction Details | |||
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Target | Acetyl-CoA carboxylase 2 | ||
Ligand | BDBM50350736 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_762997 (CHEMBL1820814) | ||
IC50 | 780±n/a nM | ||
Citation | Bengtsson, C; Blaho, S; Saitton, DB; Brickmann, K; Broddefalk, J; Davidsson, O; Drmota, T; Folmer, R; Hallberg, K; Hallén, S; Hovland, R; Isin, E; Johannesson, P; Kull, B; Larsson, LO; Löfgren, L; Nilsson, KE; Noeske, T; Oakes, N; Plowright, AT; Schnecke, V; Ståhlberg, P; Sörme, P; Wan, H; Wellner, E; Oster, L Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats. Bioorg Med Chem19:3039-53 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Acetyl-CoA carboxylase 2 | |||
Name: | Acetyl-CoA carboxylase 2 | ||
Synonyms: | ACACB | ACACB_HUMAN | ACC-beta | ACC2 | ACCB | Acetyl-CoA carboxylase | Acetyl-CoA carboxylase 2 | Acetyl-CoA carboxylase 2 (ACC) | Acetyl-CoA carboxylase 2 (ACC2) | ||
Type: | Protein | ||
Mol. Mass.: | 276535.21 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O00763 | ||
Residue: | 2458 | ||
Sequence: |
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BDBM50350736 | |||
n/a | |||
Name | BDBM50350736 | ||
Synonyms: | CHEMBL1818191 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H34N4O3 | ||
Mol. Mass. | 462.5839 | ||
SMILES | CC(C)(C)OC(=O)NC[C@H]1CC[C@H](CNC(=O)c2cc(nc3[nH]ccc23)-c2ccccc2)CC1 |r,wU:9.8,wD:12.12,(45.25,-13.23,;46.58,-12.45,;46.58,-10.91,;45.24,-11.68,;47.92,-13.22,;49.25,-12.44,;49.25,-10.9,;50.59,-13.21,;50.59,-14.75,;51.93,-15.52,;53.26,-14.74,;54.58,-15.52,;54.58,-17.06,;55.92,-17.83,;55.92,-19.37,;57.25,-20.14,;58.58,-19.37,;57.25,-21.68,;58.58,-22.44,;58.58,-23.98,;57.24,-24.75,;55.91,-23.99,;54.44,-24.46,;53.54,-23.2,;54.45,-21.96,;55.92,-22.45,;59.91,-24.74,;59.91,-26.29,;61.24,-27.05,;62.58,-26.28,;62.57,-24.73,;61.23,-23.97,;53.26,-17.82,;51.93,-17.06,)| | ||
Structure |