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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Acetyl-CoA carboxylase 2 | ||
| Ligand | BDBM50350749 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_762997 (CHEMBL1820814) | ||
| IC50 | 690±n/a nM | ||
| Citation |  Bengtsson, C; Blaho, S; Saitton, DB; Brickmann, K; Broddefalk, J; Davidsson, O; Drmota, T; Folmer, R; Hallberg, K; Hallén, S; Hovland, R; Isin, E; Johannesson, P; Kull, B; Larsson, LO; Löfgren, L; Nilsson, KE; Noeske, T; Oakes, N; Plowright, AT; Schnecke, V; Ståhlberg, P; Sörme, P; Wan, H; Wellner, E; Oster, L Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats. Bioorg Med Chem19:3039-53 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Acetyl-CoA carboxylase 2 | |||
| Name: | Acetyl-CoA carboxylase 2 | ||
| Synonyms: | ACACB | ACACB_HUMAN | ACC-beta | ACC2 | ACCB | Acetyl-CoA carboxylase | Acetyl-CoA carboxylase 2 | Acetyl-CoA carboxylase 2 (ACC) | Acetyl-CoA carboxylase 2 (ACC2) | ||
| Type: | Protein | ||
| Mol. Mass.: | 276535.21 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O00763 | ||
| Residue: | 2458 | ||
| Sequence: |
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| BDBM50350749 | |||
| n/a | |||
| Name | BDBM50350749 | ||
| Synonyms: | CHEMBL1818298 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H43N5O3 | ||
| Mol. Mass. | 509.6834 | ||
| SMILES | CC(C)(C)OC(=O)NC[C@H]1CC[C@H](CNC(=O)c2cc(nc3ccccc23)N2CCC(CN)CC2)CC1 |r,wU:9.8,wD:12.12,(-9.87,-35.11,;-8.54,-34.34,;-8.54,-32.8,;-9.88,-33.57,;-7.2,-35.11,;-5.87,-34.33,;-5.87,-32.79,;-4.53,-35.1,;-4.53,-36.64,;-3.19,-37.41,;-1.86,-36.63,;-.53,-37.41,;-.53,-38.95,;.8,-39.72,;.8,-41.26,;2.13,-42.03,;3.47,-41.26,;2.13,-43.57,;3.46,-44.33,;3.47,-45.87,;2.13,-46.65,;.79,-45.87,;-.53,-46.63,;-1.85,-45.87,;-1.85,-44.33,;-.52,-43.57,;.8,-44.34,;4.79,-46.64,;4.79,-48.18,;6.13,-48.95,;7.46,-48.17,;8.8,-48.94,;8.81,-50.48,;7.46,-46.62,;6.12,-45.86,;-1.86,-39.71,;-3.19,-38.95,)| | ||
| Structure | 
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