Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bifunctional epoxide hydrolase 2 | ||
| Ligand | BDBM50351237 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_763895 (CHEMBL1819920) | ||
| IC50 | 0.5±n/a nM | ||
| Citation |  Brown, JR; North, EJ; Hurdle, JG; Morisseau, C; Scarborough, JS; Sun, D; Korduláková, J; Scherman, MS; Jones, V; Grzegorzewicz, A; Crew, RM; Jackson, M; McNeil, MR; Lee, RE The structure-activity relationship of urea derivatives as anti-tuberculosis agents. Bioorg Med Chem19:5585-95 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bifunctional epoxide hydrolase 2 | |||
| Name: | Bifunctional epoxide hydrolase 2 | ||
| Synonyms: | Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 62613.07 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34913 | ||
| Residue: | 555 | ||
| Sequence: |
| ||
| BDBM50351237 | |||
| n/a | |||
| Name | BDBM50351237 | ||
| Synonyms: | CHEMBL1818395 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H24N2O2 | ||
| Mol. Mass. | 312.4061 | ||
| SMILES | CC(=O)c1cccc(NC(=O)NC2C3CC4CC(C3)CC2C4)c1 |TLB:21:20:18:14.15.16,THB:11:12:18:14.15.16,21:15:12.20.19:18,16:15:12:19.17.18,16:17:12:14.21.15,(25.6,-26.26,;26.93,-27.03,;26.93,-28.57,;28.27,-26.26,;28.27,-24.72,;29.6,-23.95,;30.93,-24.71,;30.94,-26.26,;32.27,-27.03,;33.61,-26.26,;33.6,-24.72,;34.94,-27.03,;36.27,-26.25,;37.47,-24.98,;38.79,-25.47,;40.19,-25.12,;40.21,-23.59,;38.8,-23.01,;37.46,-23.49,;37.76,-24.25,;37.77,-25.83,;39.18,-26.4,;29.6,-27.03,)| | ||
| Structure | 
| ||