| Reaction Details |
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 | Report a problem with these data |
| Target | Kinesin-like protein KIF11 |
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| Ligand | BDBM50351255 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_764354 (CHEMBL1820906) |
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| EC50 | 600±n/a nM |
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| Citation |  Rodriguez, D; Ramesh, C; Henson, LH; Wilmeth, L; Bryant, BK; Kadavakollu, S; Hirsch, R; Montoya, J; Howell, PR; George, JM; Alexander, D; Johnson, DL; Arterburn, JB; Shuster, CB Synthesis and characterization of tritylthioethanamine derivatives with potent KSP inhibitory activity. Bioorg Med Chem19:5446-53 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kinesin-like protein KIF11 |
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| Name: | Kinesin-like protein KIF11 |
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| Synonyms: | EG5 | KIF11 | KIF11_HUMAN | KNSL1 | Kinesin Spindle Protein Eg5 | Kinesin-like protein 1 | TRIP5 | kinesin spindle protein |
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| Type: | PROTEIN |
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| Mol. Mass.: | 119138.97 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1457426 |
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| Residue: | 1056 |
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| Sequence: | MASQPNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADK
SSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERS
PNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSE
RLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFS
VTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVIT
ALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNIL
NKPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIV
ELIEKIGAVEEELNRVTELFMDNKNELDQCKSDLQNKTQELETTQKHLQETKLQLVKEEY
ITSALESTEEKLHDAASKLLNTVEETTKDVSGLHSKLDRKKAVDQHNAEAQDIFGKNLNS
LFNNMEELIKDGSSKQKAMLEVHKTLFGNLLSSSVSALDTITTVALGSLTSIPENVSTHV
SQIFNMILKEQSLAAESKTVLQELINVLKTDLLSSLEMILSPTVVSILKINSQLKHIFKT
SLTVADKIEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNLTEDLKTIKQTHSQ
ELCKLMNLWTERFCALEEKCENIQKPLSSVQENIQQKSKDIVNKMTFHSQKFCADSDGFS
QELRNFNQEGTKLVEESVKHSDKLNGNLEKISQETEQRCESLNTRTVYFSEQWVSSLNER
EQELHNLLEVVSQCCEASSSDITEKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQNLELNE
TIKIGLTKLNCFLEQDLKLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKRKQPELLM
MLNCSENNKEETIPDVDVEEAVLGQYTEEPLSQEPSVDAGVDCSSIGGVPFFQHKKSHGK
DKENRGINTLERSKVEETTEHLVTKSRLPLRAQINL
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| BDBM50351255 |
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| n/a |
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| Name | BDBM50351255 |
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| Synonyms: | CHEMBL1818525 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23NO3S |
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| Mol. Mass. | 393.499 |
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| SMILES | COc1ccc(cc1)C(SC[C@@H](N)C(O)=O)(c1ccccc1)c1ccccc1 |r| |
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| Structure | 
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