Reaction Details | |||
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Target | Histamine H3 receptor | ||
Ligand | BDBM50352097 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_766550 (CHEMBL1827031) | ||
Ki | 0.25±n/a nM | ||
Citation | Labeeuw, O; Levoin, N; Poupardin-Olivier, O; Calmels, T; Ligneau, X; Berrebi-Bertrand, I; Robert, P; Lecomte, JM; Schwartz, JC; Capet, M Novel and highly potent histamine H3 receptor ligands. Part 2: exploring the cyclohexylamine-based series. Bioorg Med Chem Lett21:5384-8 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Histamine H3 receptor | |||
Name: | Histamine H3 receptor | ||
Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 48691.47 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Binding assays were using CHO cells stably expressing hH3R receptors. | ||
Residue: | 445 | ||
Sequence: |
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BDBM50352097 | |||
n/a | |||
Name | BDBM50352097 | ||
Synonyms: | CHEMBL1824233 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H36N2O | ||
Mol. Mass. | 356.5447 | ||
SMILES | C(COc1ccc(cc1)[C@H]1CC[C@@H](CC1)N1CCC1)CN1CCCCC1 |r,wU:12.16,wD:9.9,(16.79,-1.47,;18.33,-1.47,;19.11,-.14,;20.65,-.14,;21.41,-1.49,;22.94,-1.49,;23.72,-.16,;22.96,1.17,;21.41,1.18,;25.27,-.18,;26.03,-1.52,;27.56,-1.53,;28.34,-.2,;27.58,1.14,;26.04,1.15,;29.88,-.22,;30.96,-1.32,;32.06,-.24,;30.98,.86,;16.03,-.14,;14.49,-.14,;13.72,-1.46,;12.18,-1.46,;11.41,-.14,;12.18,1.2,;13.72,1.2,)| | ||
Structure |