Reaction Details |
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Target | Aurora kinase B |
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Ligand | BDBM50352301 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_766653 (CHEMBL1827219) |
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Kd | 49±n/a nM |
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Citation | Abraham, S; Hadd, MJ; Tran, L; Vickers, T; Sindac, J; Milanov, ZV; Holladay, MW; Bhagwat, SS; Hua, H; Ford Pulido, JM; Cramer, MD; Gitnick, D; James, J; Dao, A; Belli, B; Armstrong, RC; Treiber, DK; Liu, G Novel series of pyrrolotriazine analogs as highly potent pan-Aurora kinase inhibitors. Bioorg Med Chem Lett21:5296-300 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aurora kinase B |
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Name: | Aurora kinase B |
Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
Type: | Protein |
Mol. Mass.: | 39327.72 |
Organism: | Homo sapiens (Human) |
Description: | Q96GD4 |
Residue: | 344 |
Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
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BDBM50352301 |
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n/a |
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Name | BDBM50352301 |
Synonyms: | CHEMBL1822488 |
Type | Small organic molecule |
Emp. Form. | C26H29N9O2S |
Mol. Mass. | 531.633 |
SMILES | Cc1cc(Nc2nc(Sc3ccc(NC(=O)C4CC4)cc3)nn3cc(NC(=O)CN4CCCC4)cc23)[nH]n1 |
Structure |
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