| Reaction Details |
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 | Report a problem with these data |
| Target | Transcriptional regulator ERG |
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| Ligand | BDBM50352296 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_766760 |
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| IC50 | >30000±n/a nM |
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| Citation |  Ontoria, JM; Bufi, LL; Torrisi, C; Bresciani, A; Giomini, C; Rowley, M; Serafini, S; Bin, H; Hao, W; Steinkühler, C; Jones, P Identification of a series of 4-[3-(quinolin-2-yl)-1,2,4-oxadiazol-5-yl]piperazinyl ureas as potent smoothened antagonist hedgehog pathway inhibitors. Bioorg Med Chem Lett21:5274-82 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transcriptional regulator ERG |
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| Name: | Transcriptional regulator ERG |
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| Synonyms: | ERG | ERG_HUMAN | Transforming protein ERG |
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| Type: | PROTEIN |
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| Mol. Mass.: | 54615.84 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1335569 |
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| Residue: | 486 |
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| Sequence: | MIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQ
QDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHM
PPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTK
DDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPN
TSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPY
QILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGE
RKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPS
DLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPS
HLGTYY
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| BDBM50352296 |
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| n/a |
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| Name | BDBM50352296 |
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| Synonyms: | CHEMBL1822468 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24F2N6O2 |
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| Mol. Mass. | 442.4618 |
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| SMILES | FC1(F)CCC(CC1)NC(=O)N1CCN(CC1)c1nc(no1)-c1ccc2ccccc2n1 |
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| Structure | 
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