| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Beta-secretase 2 |
|---|
| Ligand | BDBM50352854 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_767494 (CHEMBL1825606) |
|---|
| IC50 | 50±n/a nM |
|---|
| Citation |  Malamas, MS; Erdei, J; Gunawan, I; Barnes, K; Hui, Y; Johnson, M; Robichaud, A; Zhou, P; Yan, Y; Solvibile, W; Turner, J; Fan, KY; Chopra, R; Bard, J; Pangalos, MN New pyrazolyl and thienyl aminohydantoins as potent BACE1 inhibitors: exploring the S2' region. Bioorg Med Chem Lett21:5164-70 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Beta-secretase 2 |
|---|
| Name: | Beta-secretase 2 |
|---|
| Synonyms: | AEPLC | ALP56 | ASP1 | ASP21 | Asp 1 | Aspartic-like protease 56 kDa | Aspartyl protease 1 | BACE2 | BACE2_HUMAN | Beta secretase 2 | Beta-secretase (BACE) | Beta-secretase 2 | Beta-secretase 2 (BACE-2) | Beta-secretase 2 precursor | Beta-site APP-cleaving enzyme 2 | Down region aspartic protease | Memapsin-1 | Membrane-associated aspartic protease 1 | beta-Secretase (BACE-2) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 56171.20 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9Y5Z0 |
|---|
| Residue: | 518 |
|---|
| Sequence: | MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGL
ALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAG
TPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATI
FESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVA
GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA
IVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISI
YLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFD
RAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCG
AILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK
|
|
|
|---|
| BDBM50352854 |
|---|
| n/a |
|---|
| Name | BDBM50352854 |
|---|
| Synonyms: | CHEMBL1824361 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H19FN4O2S |
|---|
| Mol. Mass. | 422.475 |
|---|
| SMILES | CCC(=O)c1cc(cs1)[C@@]1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1F |r,t:11| |
|---|
| Structure | 
|
|---|
Search and Browse
