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TargetPolyamine deacetylase HDAC10
LigandBDBM50248570
Substrate/Competitorn/a
Meas. Tech.ChEMBL_769066 (CHEMBL1832529)
Ki 23±n/a nM
Citation Wang, HYu, NChen, DLee, KCLye, PLChang, JWDeng, WNg, MCLu, TKhoo, MLPoulsen, ASangthongpitag, KWu, XHu, CGoh, KCWang, XFang, LGoh, KLKhng, HHGoh, SKYeo, PLiu, XBonday, ZWood, JMDymock, BWKantharaj, ESun, ET Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile. J Med Chem54:4694-720 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Polyamine deacetylase HDAC10
Name:Polyamine deacetylase HDAC10
Synonyms:HD10 | HDA10_HUMAN | HDAC10 | Histone deacetylase | Histone deacetylase 10 | Human HDAC10
Type:Chromatin regulator; hydrolase; repressor
Mol. Mass.:71431.89
Organism:Homo sapiens (Human)
Description:Q969S8
Residue:669
Sequence:
MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL
GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG
AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ
YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA
AFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAV
LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ
DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD
ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA
ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS
MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL
AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM
LQCHPHLVA
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  Blast E-value cutoff:
BDBM50248570
n/a
NameBDBM50248570
Synonyms:3-(1-(3-(dimethylamino)-2,2-dimethylpropyl)-2-phenethyl-1H-benzo[d]imidazol-5-yl)-N-hydroxyacrylamide | CHEMBL460963 | US10201527, Compound 17 | US10736881, Compound 17 | US8551988, 17
TypeSmall organic molecule
Emp. Form.C25H32N4O2
Mol. Mass.420.5472
SMILESCN(C)CC(C)(C)Cn1c(CCc2ccccc2)nc2cc(\C=C\C(=O)NO)ccc12
Structure
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