| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase 11 |
|---|
| Ligand | BDBM50353233 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_769067 (CHEMBL1832530) |
|---|
| Ki | 8.8±n/a nM |
|---|
| Citation |  Wang, H; Yu, N; Chen, D; Lee, KC; Lye, PL; Chang, JW; Deng, W; Ng, MC; Lu, T; Khoo, ML; Poulsen, A; Sangthongpitag, K; Wu, X; Hu, C; Goh, KC; Wang, X; Fang, L; Goh, KL; Khng, HH; Goh, SK; Yeo, P; Liu, X; Bonday, Z; Wood, JM; Dymock, BW; Kantharaj, E; Sun, ET Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile. J Med Chem54:4694-720 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone deacetylase 11 |
|---|
| Name: | Histone deacetylase 11 |
|---|
| Synonyms: | HD11 | HDA11_HUMAN | HDAC11 | Human HDAC11 |
|---|
| Type: | Chromatin regulator; hydrolase; repressor |
|---|
| Mol. Mass.: | 39187.66 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q96DB2 |
|---|
| Residue: | 347 |
|---|
| Sequence: | MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML
VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG
TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL
DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER
NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT
SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
|
|
|
|---|
| BDBM50353233 |
|---|
| n/a |
|---|
| Name | BDBM50353233 |
|---|
| Synonyms: | CHEMBL1830536 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H28N4O2 |
|---|
| Mol. Mass. | 356.4619 |
|---|
| SMILES | CCNCCn1c(CC\C=C/CC)nc2cc(\C=C\C(=O)NO)ccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
