| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 26A1 |
|---|
| Ligand | BDBM50176808 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_769532 (CHEMBL1833279) |
|---|
| IC50 | 540±n/a nM |
|---|
| Citation |  Gomaa, MS; Bridgens, CE; Veal, GJ; Redfern, CP; Brancale, A; Armstrong, JL; Simons, C Synthesis and biological evaluation of 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propyl derivatives as small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26). J Med Chem54:6803-11 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 26A1 |
|---|
| Name: | Cytochrome P450 26A1 |
|---|
| Synonyms: | CP26A_HUMAN | CYP26 | CYP26A1 | Cytochrome CYP26A1 | Cytochrome P450 26A1 | Cytochrome P450 retinoic acid-inactivating 1 | P450RAI1 | Retinoic acid 4-hydroxylase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 56216.16 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O43174 |
|---|
| Residue: | 497 |
|---|
| Sequence: | MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQM
VLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTIL
GSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPE
VKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKAR
NLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFG
GHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVI
KETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFM
LPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTV
YPVDNLPARFTHFHGEI
|
|
|
|---|
| BDBM50176808 |
|---|
| n/a |
|---|
| Name | BDBM50176808 |
|---|
| Synonyms: | 5-[(3-Chloro-phenyl)-imidazol-1-yl-methyl]-1H-benzoimidazole | 6-((3-chlorophenyl)(1H-imidazol-1-yl)methyl)-1H-benzo[d]imidazole | CHEMBL389433 | US9138393, Liarizole hydrochloride | US9144538, Liarizole hydrochloride | liarozole |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H13ClN4 |
|---|
| Mol. Mass. | 308.765 |
|---|
| SMILES | Clc1cccc(c1)C(c1ccc2nc[nH]c2c1)n1ccnc1 |
|---|
| Structure | 
|
|---|
Search and Browse
