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TargetCytochrome P450 26A1
LigandBDBM50342133
Substrate/Competitorn/a
Meas. Tech.ChEMBL_769613 (CHEMBL1833546)
IC50 10±n/a nM
Citation Gomaa, MS; Bridgens, CE; Veal, GJ; Redfern, CP; Brancale, A; Armstrong, JL; Simons, C Synthesis and biological evaluation of 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propyl derivatives as small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26). J Med Chem54:6803-11 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 26A1
Name:Cytochrome P450 26A1
Synonyms:CP26A_HUMAN | CYP26 | CYP26A1 | Cytochrome CYP26A1 | Cytochrome P450 26A1 | Cytochrome P450 retinoic acid-inactivating 1 | P450RAI1 | Retinoic acid 4-hydroxylase
Type:Enzyme
Mol. Mass.:56216.16
Organism:Homo sapiens (Human)
Description:O43174
Residue:497
Sequence:
MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQM
VLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTIL
GSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPE
VKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKAR
NLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFG
GHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVI
KETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFM
LPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTV
YPVDNLPARFTHFHGEI
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  Blast E-value cutoff:
BDBM50342133
n/a
NameBDBM50342133
Synonyms:Benzothiazol-2-yl-[4-((1S,2S)-2-dimethylamino-1-imidazol-1-yl-propyl)-phenyl]-amine | CHEMBL517438 | N-(4-((1R,2R)-2-(dimethylamino)-1-(1H-imidazol-1-yl)propyl)phenyl)benzo[d]thiazol-2-amine | R-116010
TypeSmall organic molecule
Emp. Form.C21H23N5S
Mol. Mass.377.506
SMILESC[C@H]([C@@H](c1ccc(Nc2nc3ccccc3s2)cc1)n1ccnc1)N(C)C |r|
Structure
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