| Reaction Details |
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 | Report a problem with these data |
| Target | Mu-type opioid receptor |
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| Ligand | BDBM50353656 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_770074 (CHEMBL1832554) |
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| Ki | 2600±n/a nM |
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| Citation |  Malinka, W; Redzicka, A; Jastrzebska-Wiesek, M; Filipek, B; Dybala, M; Karczmarzyk, Z; Urbanczyk-Lipkowska, Z; Kalicki, P Derivatives of pyrrolo[3,4-d]pyridazinone, a new class of analgesic agents. Eur J Med Chem46:4992-9 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mu-type opioid receptor |
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| Name: | Mu-type opioid receptor |
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| Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44503.11 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. |
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| Residue: | 398 |
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| Sequence: | MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
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| BDBM50353656 |
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| n/a |
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| Name | BDBM50353656 |
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| Synonyms: | CHEMBL1829950 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H30ClN5O2 |
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| Mol. Mass. | 492.012 |
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| SMILES | Cc1n(c(C)c2c1c(=O)[nH]n(CCN1CCN(CC1)c1cc(Cl)ccc1C)c2=O)-c1ccccc1 |
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| Structure | 
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