| Reaction Details |
|---|
 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4A |
|---|
| Ligand | BDBM14774 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_769284 (CHEMBL1833211) |
|---|
| IC50 | 0.59±n/a nM |
|---|
| Citation |  Taltavull, J; Serrat, J; Gràcia, J; Gavaldà, A; Córdoba, M; Calama, E; Montero, JL; Andrés, M; Miralpeix, M; Vilella, D; Hernández, B; Beleta, J; Ryder, H; Pagès, L Synthesis and biological activity of pyrido[3',2':4,5]furo[3,2-d]pyrimidine derivatives as novel and potent phosphodiesterase type 4 inhibitors. Eur J Med Chem46:4946-56 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A |
|---|
| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4A |
|---|
| Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE2 | PDE46 | PDE4A | PDE4A_HUMAN | Phosphodiesterase 4 (PDE4) | Phosphodiesterase 4A | Phosphodiesterase 4A (PDE4) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 98113.27 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P27815 |
|---|
| Residue: | 886 |
|---|
| Sequence: | MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQ
PHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGR
SPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTP
FAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDW
CLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEI
PSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTD
QEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYML
TLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGV
SNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDM
VLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLE
LYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADL
VHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEE
ISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLT
QQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLP
STAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT
|
|
|
|---|
| BDBM14774 |
|---|
| n/a |
|---|
| Name | BDBM14774 |
|---|
| Synonyms: | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide | CHEMBL193240 | DAXAS | ROF | Roflumilast |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H14Cl2F2N2O3 |
|---|
| Mol. Mass. | 403.207 |
|---|
| SMILES | FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1c(Cl)cncc1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
