| Reaction Details |
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 | Report a problem with these data |
| Target | Kinesin-like protein KIF23 |
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| Ligand | BDBM50353788 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_770434 (CHEMBL1833743) |
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| IC50 | 50000±n/a nM |
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| Citation |  Theoclitou, ME; Aquila, B; Block, MH; Brassil, PJ; Castriotta, L; Code, E; Collins, MP; Davies, AM; Deegan, T; Ezhuthachan, J; Filla, S; Freed, E; Hu, H; Huszar, D; Jayaraman, M; Lawson, D; Lewis, PM; Nadella, MV; Oza, V; Padmanilayam, M; Pontz, T; Ronco, L; Russell, D; Whitston, D; Zheng, X Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent. J Med Chem54:6734-50 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kinesin-like protein KIF23 |
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| Name: | Kinesin-like protein KIF23 |
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| Synonyms: | KIF23 | KIF23_HUMAN | KNSL5 | MKLP1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 110080.28 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_770434 |
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| Residue: | 960 |
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| Sequence: | MKSARAKTPRKPTVKKGSQTNLKDPVGVYCRVRPLGFPDQECCIEVINNTTVQLHTPEGY
RLNRNGDYKETQYSFKQVFGTHTTQKELFDVVANPLVNDLIHGKNGLLFTYGVTGSGKTH
TMTGSPGEGGLLPRCLDMIFNSIGSFQAKRYVFKSNDRNSMDIQCEVDALLERQKREAMP
NPKTSSSKRQVDPEFADMITVQEFCKAEEVDEDSVYGVFVSYIEIYNNYIYDLLEEVPFD
PIKPKPPQSKLLREDKNHNMYVAGCTEVEVKSTEEAFEVFWRGQKKRRIANTHLNRESSR
SHSVFNIKLVQAPLDADGDNVLQEKEQITISQLSLVDLAGSERTNRTRAEGNRLREAGNI
NQSLMTLRTCMDVLRENQMYGTNKMVPYRDSKLTHLFKNYFDGEGKVRMIVCVNPKAEDY
EENLQVMRFAEVTQEVEVARPVDKAICGLTPGRRYRNQPRGPVGNEPLVTDVVLQSFPPL
PSCEILDINDEQTLPRLIEALEKRHNLRQMMIDEFNKQSNAFKALLQEFDNAVLSKENHM
QGKLNEKEKMISGQKLEIERLEKKNKTLEYKIEILEKTTTIYEEDKRNLQQELETQNQKL
QRQFSDKRRLEARLQGMVTETTMKWEKECERRVAAKQLEMQNKLWVKDEKLKQLKAIVTE
PKTEKPERPSRERDREKVTQRSVSPSPVPLSSNYIAQISNGQQLMSQPQLHRRSNSCSSI
SVASCISEWEQKIPTYNTPLKVTSIARRRQQEPGQSKTCIVSDRRRGMYWTEGREVVPTF
RNEIEIEEDHCGRLLFQPDQNAPPIRLRHRRSRSAGDRWVDHKPASNMQTETVMQPHVPH
AITVSVANEKALAKCEKYMLTHQELASDGEIETKLIKGDIYKTRGGGQSVQFTDIETLKQ
ESPNGSRKRRSSTVAPAQPDGAESEWTDVETRCSVAVEMRAGSQLGPGYQHHAQPKRKKP
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| BDBM50353788 |
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| n/a |
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| Name | BDBM50353788 |
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| Synonyms: | CHEMBL1829433 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H33N5O2S |
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| Mol. Mass. | 503.659 |
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| SMILES | CC(C)C(N(CCCN)C(=O)c1ccc(C)cc1)c1nc2snc(C)c2c(=O)n1Cc1ccccc1 |
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| Structure | 
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