Reaction Details |
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Target | Sodium-dependent dopamine transporter |
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Ligand | BDBM50319578 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_769844 (CHEMBL1831838) |
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IC50 | 2113±n/a nM |
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Citation | O'Neill, DJ; Adedoyin, A; Bray, JA; Deecher, DC; Fensome, A; Goldberg, JA; Harrison, J; Leventhal, L; Mann, C; Mark, L; Nogle, L; Sullivan, NR; Spangler, TB; Terefenko, EA; Trybulski, EJ; Uveges, AJ; Vu, A; Whiteside, GT; Zhang, P Discovery of novel selective norepinephrine inhibitors: 1-(2-morpholin-2-ylethyl)-3-aryl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxides (WYE-114152). J Med Chem54:6824-31 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent dopamine transporter |
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Name: | Sodium-dependent dopamine transporter |
Synonyms: | DA transporter | DAT | DAT1 | Dopamine transporter (DAT) | Dopamine transporter protein (DAT) | Monoamine transporter | SC6A3_HUMAN | SLC6A3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) | Solute carrier family 6 member 3 |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 68497.11 |
Organism: | Homo sapiens (Human) |
Description: | Q01959 |
Residue: | 620 |
Sequence: | MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDR
ETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC
NNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQL
TACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSV
DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSS
GFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGI
DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAA
GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI
VTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD
RELVDRGEVRQFTLRHWLKV
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BDBM50319578 |
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n/a |
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Name | BDBM50319578 |
Synonyms: | (2S)-(4-[3-(2-Fluorophenyl)-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-1-(methylamino)butan-2-ol | CHEMBL1082458 |
Type | Small organic molecule |
Emp. Form. | C17H20FN3O3S |
Mol. Mass. | 365.422 |
SMILES | CNC[C@@H](O)CCN1c2ccccc2N(c2ccccc2F)S1(=O)=O |r| |
Structure |
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