Reaction Details | |||
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Target | Hypoxia-inducible factor 1-alpha | ||
Ligand | BDBM50354124 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_770820 (CHEMBL1837625) | ||
IC50 | 27500±n/a nM | ||
Citation | Huang, W; Huang, R; Attene-Ramos, MS; Sakamuru, S; Englund, EE; Inglese, J; Austin, CP; Xia, M Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1a inhibitors. Bioorg Med Chem Lett21:5239-43 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Hypoxia-inducible factor 1-alpha | |||
Name: | Hypoxia-inducible factor 1-alpha | ||
Synonyms: | BHLHE78 | HIF-1-alpha | HIF-1-alpha, HIF-2-alpha | HIF1A | HIF1A_HUMAN | Hypoxia inducible factors | Hypoxia-inducible factor 1 alpha | Hypoxia-inducible factor 1-alpha | MOP1 | PASD8 | von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A | ||
Type: | Protein | ||
Mol. Mass.: | 92647.24 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q16665 | ||
Residue: | 826 | ||
Sequence: |
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BDBM50354124 | |||
n/a | |||
Name | BDBM50354124 | ||
Synonyms: | CHEMBL1836237 | ||
Type | Small organic molecule | ||
Emp. Form. | C28H30N4O2 | ||
Mol. Mass. | 454.5634 | ||
SMILES | CCOc1ccccc1-n1c(CN2CCN(Cc3ccccc3)CC2)nc2ccccc2c1=O |(5.33,2.69,;4,1.92,;2.67,2.69,;2.67,4.23,;4,5,;4,6.54,;2.67,7.32,;1.33,6.55,;1.33,5,;,4.23,;,2.69,;1.33,1.92,;1.33,.38,;,-.39,;,-1.93,;1.33,-2.7,;1.33,-4.24,;2.67,-5.01,;2.67,-6.55,;4,-7.32,;5.33,-6.55,;5.33,-5.01,;4,-4.23,;2.67,-1.93,;2.67,-.39,;-1.33,1.92,;-2.67,2.69,;-4,1.92,;-5.33,2.69,;-5.33,4.23,;-4,5,;-2.67,4.23,;-1.33,5.01,;-1.33,6.54,)| | ||
Structure |