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TargetHypoxia-inducible factor 1-alpha
LigandBDBM50354128
Substrate/Competitorn/a
Meas. Tech.ChEMBL_770820 (CHEMBL1837625)
IC50 200±n/a nM
Citation Huang, WHuang, RAttene-Ramos, MSSakamuru, SEnglund, EEInglese, JAustin, CPXia, M Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1a inhibitors. Bioorg Med Chem Lett21:5239-43 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Hypoxia-inducible factor 1-alpha
Name:Hypoxia-inducible factor 1-alpha
Synonyms:BHLHE78 | HIF-1-alpha | HIF-1-alpha, HIF-2-alpha | HIF1A | HIF1A_HUMAN | Hypoxia inducible factors | Hypoxia-inducible factor 1 alpha | Hypoxia-inducible factor 1-alpha | MOP1 | PASD8 | von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A
Type:Protein
Mol. Mass.:92647.24
Organism:Homo sapiens (Human)
Description:Q16665
Residue:826
Sequence:
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM
RLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM
GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK
TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET
DDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEP
NPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVT
VFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYR
DTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKR
KMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLAC
RLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
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  Blast E-value cutoff:
BDBM50354128
n/a
NameBDBM50354128
Synonyms:CHEMBL1836179
TypeSmall organic molecule
Emp. Form.C21H21F3N4O2
Mol. Mass.418.4122
SMILESCOc1ccc(cc1-n1c(CN2CCNCC2)nc2ccccc2c1=O)C(F)(F)F |(4.67,-1.92,;3.33,-1.15,;3.33,.39,;4.67,1.16,;4.67,2.7,;3.33,3.47,;2,2.7,;2,1.16,;.67,.39,;.67,-1.15,;2,-1.92,;2,-3.46,;.67,-4.24,;.67,-5.77,;2,-6.55,;3.33,-5.78,;3.33,-4.23,;-.67,-1.93,;-2,-1.16,;-3.33,-1.93,;-4.67,-1.15,;-4.67,.39,;-3.33,1.16,;-2,.39,;-.67,1.16,;-.67,2.7,;3.33,5.01,;2,5.78,;4.67,5.78,;3.33,6.55,)|
Structure
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