Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Hypoxia-inducible factor 1-alpha | ||
Ligand | BDBM50354128 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_770820 (CHEMBL1837625) | ||
IC50 | 200±n/a nM | ||
Citation | Huang, W; Huang, R; Attene-Ramos, MS; Sakamuru, S; Englund, EE; Inglese, J; Austin, CP; Xia, M Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1a inhibitors. Bioorg Med Chem Lett21:5239-43 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Hypoxia-inducible factor 1-alpha | |||
Name: | Hypoxia-inducible factor 1-alpha | ||
Synonyms: | BHLHE78 | HIF-1-alpha | HIF-1-alpha, HIF-2-alpha | HIF1A | HIF1A_HUMAN | Hypoxia inducible factors | Hypoxia-inducible factor 1 alpha | Hypoxia-inducible factor 1-alpha | MOP1 | PASD8 | von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A | ||
Type: | Protein | ||
Mol. Mass.: | 92647.24 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q16665 | ||
Residue: | 826 | ||
Sequence: |
| ||
BDBM50354128 | |||
n/a | |||
Name | BDBM50354128 | ||
Synonyms: | CHEMBL1836179 | ||
Type | Small organic molecule | ||
Emp. Form. | C21H21F3N4O2 | ||
Mol. Mass. | 418.4122 | ||
SMILES | COc1ccc(cc1-n1c(CN2CCNCC2)nc2ccccc2c1=O)C(F)(F)F |(4.67,-1.92,;3.33,-1.15,;3.33,.39,;4.67,1.16,;4.67,2.7,;3.33,3.47,;2,2.7,;2,1.16,;.67,.39,;.67,-1.15,;2,-1.92,;2,-3.46,;.67,-4.24,;.67,-5.77,;2,-6.55,;3.33,-5.78,;3.33,-4.23,;-.67,-1.93,;-2,-1.16,;-3.33,-1.93,;-4.67,-1.15,;-4.67,.39,;-3.33,1.16,;-2,.39,;-.67,1.16,;-.67,2.7,;3.33,5.01,;2,5.78,;4.67,5.78,;3.33,6.55,)| | ||
Structure |