Reaction Details | |||
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Target | Hypoxia-inducible factor 1-alpha | ||
Ligand | BDBM50354129 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_770820 (CHEMBL1837625) | ||
IC50 | 4200±n/a nM | ||
Citation | Huang, W; Huang, R; Attene-Ramos, MS; Sakamuru, S; Englund, EE; Inglese, J; Austin, CP; Xia, M Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1a inhibitors. Bioorg Med Chem Lett21:5239-43 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Hypoxia-inducible factor 1-alpha | |||
Name: | Hypoxia-inducible factor 1-alpha | ||
Synonyms: | BHLHE78 | HIF-1-alpha | HIF-1-alpha, HIF-2-alpha | HIF1A | HIF1A_HUMAN | Hypoxia inducible factors | Hypoxia-inducible factor 1 alpha | Hypoxia-inducible factor 1-alpha | MOP1 | PASD8 | von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A | ||
Type: | Protein | ||
Mol. Mass.: | 92647.24 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q16665 | ||
Residue: | 826 | ||
Sequence: |
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BDBM50354129 | |||
n/a | |||
Name | BDBM50354129 | ||
Synonyms: | CHEMBL1836180 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H21N5O4 | ||
Mol. Mass. | 395.4118 | ||
SMILES | COc1ccc(cc1-n1c(CN2CCNCC2)nc2ccccc2c1=O)[N+]([O-])=O |(4.67,-1.54,;3.33,-.77,;3.33,.77,;4.67,1.54,;4.67,3.08,;3.33,3.85,;2,3.08,;2,1.54,;.67,.77,;.67,-.77,;2,-1.54,;2,-3.08,;.67,-3.85,;.67,-5.39,;2,-6.16,;3.33,-5.39,;3.33,-3.85,;-.67,-1.54,;-2,-.77,;-3.33,-1.54,;-4.67,-.77,;-4.67,.77,;-3.33,1.54,;-2,.77,;-.67,1.54,;-.67,3.08,;3.33,5.39,;4.67,6.16,;2,6.16,)| | ||
Structure |