| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50354210 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_770621 (CHEMBL1839631) |
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| Ki | 4.2±n/a nM |
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| Citation |  Zhou, D; Gross, JL; Sze, JY; Adedoyin, AB; Bowlby, M; Di, L; Platt, BJ; Zhang, G; Brandon, N; Comery, TA; Robichaud, AJ Pyrrolidin-3-yl-N-methylbenzamides as potent histamine 3 receptor antagonists. Bioorg Med Chem Lett21:5957-60 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48691.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
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| Residue: | 445 |
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| Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
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| BDBM50354210 |
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| n/a |
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| Name | BDBM50354210 |
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| Synonyms: | CHEMBL1836035 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H28N4O |
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| Mol. Mass. | 376.4946 |
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| SMILES | CC(C)N1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-n1c(C)nc2ccccc12 |r| |
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| Structure | 
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