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TargetProtein-tyrosine kinase 6
LigandBDBM50354445
Substrate/Competitorn/a
Meas. Tech.ChEMBL_771345 (CHEMBL1839617)
IC50 8±n/a nM
Citation Zeng, HBelanger, DBCurran, PJShipps, GWMiao, HBracken, JBArshad Siddiqui, MMalkowski, MWang, Y Discovery of novel imidazo[1,2-a]pyrazin-8-amines as Brk/PTK6 inhibitors. Bioorg Med Chem Lett21:5870-5 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protein-tyrosine kinase 6
Name:Protein-tyrosine kinase 6
Synonyms:BRK | Breast tumor kinase | KH domain-containing, RNA-binding, signal transduction-associated protein 1 | PTK6 | PTK6_HUMAN | Protein-tyrosine kinase 6 (BRK) | Tyrosine Kinase BRK | Tyrosine-protein kinase 6 | Tyrosine-protein kinase BRK
Type:Tyrosine-protein kinase
Mol. Mass.:51839.11
Organism:Homo sapiens (Human)
Description:n/a
Residue:451
Sequence:
MVSRDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQG
YVPHNYLAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRD
TQAVRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPH
WDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMK
KLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGM
CYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALS
RGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLM
LTCWCRDPEQRPCFKALRERLSSFTSYENPT
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  Blast E-value cutoff:
BDBM50354445
n/a
NameBDBM50354445
Synonyms:CHEMBL1836810
TypeSmall organic molecule
Emp. Form.C21H20ClN7O2
Mol. Mass.437.882
SMILESCc1cn2c(cnc2c(Nc2ccc(C(=O)N3CCOCC3)c(Cl)c2)n1)-c1cn[nH]c1
Structure
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