| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 6 |
|---|
| Ligand | BDBM50354621 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_771219 (CHEMBL1839301) |
|---|
| Ki | 92±n/a nM |
|---|
| Citation |  van Loevezijn, A; Venhorst, J; Iwema Bakker, WI; de Korte, CG; de Looff, W; Verhoog, S; van Wees, JW; van Hoeve, M; van de Woestijne, RP; van der Neut, MA; Borst, AJ; van Dongen, MJ; de Bruin, NM; Keizer, HG; Kruse, CG N'-(arylsulfonyl)pyrazoline-1-carboxamidines as novel, neutral 5-hydroxytryptamine 6 receptor (5-HT6R) antagonists with unique structural features. J Med Chem54:7030-54 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 5-hydroxytryptamine receptor 6 |
|---|
| Name: | 5-hydroxytryptamine receptor 6 |
|---|
| Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 46968.43 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P50406 |
|---|
| Residue: | 440 |
|---|
| Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
|
|
|
|---|
| BDBM50354621 |
|---|
| n/a |
|---|
| Name | BDBM50354621 |
|---|
| Synonyms: | CHEMBL1834222 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H21ClN4O2S |
|---|
| Mol. Mass. | 404.914 |
|---|
| SMILES | CCC1CN(N=C1)C(NS(=O)(=O)c1ccccc1Cl)=NCc1ccccc1 |w:19.21,c:5| |
|---|
| Structure | 
|
|---|
Search and Browse
