Ki Summary

Reaction Details

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Target

Cannabinoid receptor 2

Ligand

BDBM50354807

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_771754 (CHEMBL1838496)

1790±n/a nM

Citation

Fulp, A; Bortoff, K; Zhang, Y; Seltzman, H; Snyder, R; Maitra, R Towards rational design of cannabinoid receptor 1 (CB1) antagonists for peripheral selectivity. Bioorg Med Chem Lett21:5711-4 (2011) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Cannabinoid receptor 2

Name:

Cannabinoid receptor 2

Synonyms:

CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

39690.94

Organism:

Homo sapiens (Human)

Description:

P34972

Residue:

360

Sequence:

MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILS
SHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTAS
VGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCS
ELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLD
VRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYA
LRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC

BDBM50354807

n/a

Name

BDBM50354807

Synonyms:

CHEMBL1834277

Type

Small organic molecule

Emp. Form.

C25H28Cl3N5O3S

Mol. Mass.

584.946

SMILES

Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl)C(=O)NC[C@H]1CC[C@@H](CNS(N)(=O)=O)CC1 |r,wU:25.27,28.31,(28.13,-41.38,;29.03,-42.62,;30.58,-42.61,;31.05,-44.08,;29.82,-44.99,;28.56,-44.08,;27.19,-44.77,;25.85,-44.01,;24.52,-44.8,;24.54,-46.34,;23.22,-47.12,;25.89,-47.09,;27.21,-46.3,;29.82,-46.53,;28.5,-47.3,;28.49,-48.85,;29.83,-49.62,;29.83,-51.16,;31.16,-48.85,;31.16,-47.3,;32.49,-46.52,;31.34,-41.27,;30.56,-39.95,;32.88,-41.26,;33.66,-42.59,;35.2,-42.58,;35.95,-41.24,;37.49,-41.23,;38.27,-42.57,;39.81,-42.56,;40.58,-41.22,;42.12,-41.22,;42.88,-39.88,;42.1,-42.75,;43.65,-41.21,;37.5,-43.9,;35.97,-43.91,)|

Structure