| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50121062 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_771084 (CHEMBL1838745) |
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| IC50 | 1500±n/a nM |
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| Citation |  Ilies, M; Dowling, DP; Lombardi, PM; Christianson, DW Synthesis of a new trifluoromethylketone analogue of l-arginine and contrasting inhibitory activity against human arginase I and histone deacetylase 8. Bioorg Med Chem Lett21:5854-8 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50121062 |
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| n/a |
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| Name | BDBM50121062 |
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| Synonyms: | 9,9,9-TRIFLUORO-8-OXO-N-PHENYLNONANAMIDE | 9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide | CHEMBL113537 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H18F3NO2 |
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| Mol. Mass. | 301.3041 |
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| SMILES | FC(F)(F)C(=O)CCCCCCC(=O)Nc1ccccc1 |
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| Structure | 
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