| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Plasminogen activator inhibitor 1 |
|---|
| Ligand | BDBM50139534 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_771275 (CHEMBL1839463) |
|---|
| IC50 | 500±n/a nM |
|---|
| Citation |  Pandya, V; Jain, M; Chakrabarti, G; Soni, H; Parmar, B; Chaugule, B; Patel, J; Joshi, J; Joshi, N; Rath, A; Raviya, M; Shaikh, M; Sairam, KV; Patel, H; Patel, P Discovery of inhibitors of plasminogen activator inhibitor-1: structure-activity study of 5-nitro-2-phenoxybenzoic acid derivatives. Bioorg Med Chem Lett21:5701-6 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Plasminogen activator inhibitor 1 |
|---|
| Name: | Plasminogen activator inhibitor 1 |
|---|
| Synonyms: | Endothelial plasminogen activator inhibitor | PAI | PAI-1 | PAI1 | PAI1_HUMAN | PLANH1 | Plasminogen activator inhibitor 1 | Plasminogen activator inhibitor 1 (PAI-1) | Plasminogen activator inhibitor-1 | Plasminogen activator-1 (PAI-1) | SERPINE1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 45064.00 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P05121 |
|---|
| Residue: | 402 |
|---|
| Sequence: | MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY
GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI
FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV
DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD
GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK
FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS
STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
|
|
|
|---|
| BDBM50139534 |
|---|
| n/a |
|---|
| Name | BDBM50139534 |
|---|
| Synonyms: | 2-[2-Methoxy-6-({3-trifluoromethyl-4-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-phenylamino}-methyl)-phenoxy]-5-nitro-benzoic acid | CHEMBL349130 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C33H28F6N4O6 |
|---|
| Mol. Mass. | 690.589 |
|---|
| SMILES | COc1cccc(CNc2ccc(N3CCN(CC3)c3cccc(c3)C(F)(F)F)c(c2)C(F)(F)F)c1Oc1ccc(cc1C(O)=O)[N+]([O-])=O |
|---|
| Structure | 
|
|---|
Search and Browse
