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TargetVasopressin V1a receptor
LigandBDBM50354906
Substrate/Competitorn/a
Meas. Tech.ChEMBL_772742
IC50 135±n/a nM
Citation Johnson PSRyckmans TBryans JBeal DMDack KNFeeder NHarrison ALewis MMason HJMills JNewman JPasquinet CRawson DJRoberts LRRussell RSpark DStobie AUnderwood TJWard RWheeler S Discovery of PF-184563, a potent and selective V1a antagonist for the treatment of dysmenorrhoea. The influence of compound flexibility on microsomal stability. Bioorg Med Chem Lett 21:5684-7 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Vasopressin V1a receptor
Name:Vasopressin V1a receptor
Synonyms:AVPR V1a | AVPR1 | AVPR1A | Antidiuretic hormone receptor 1a | V1aR | VASOPRESSIN V1A | Vascular/hepatic-type arginine vasopressin receptor | Vasopressin V1 receptor
Type:Receptor
Mol. Mass.:46820.18
Organism:Homo sapiens (Human)
Description:P37288
Residue:418
Sequence:
MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAV
TFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGP
DWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFV
LSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFIC
YNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAY
IVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCV
QSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST
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BDBM50354906
n/a
NameBDBM50354906
Synonyms:CHEMBL1837030
TypeSmall organic molecule
Emp. Form.C21H23N5O2
Mol. Mass.377.4396
SMILESCOc1ccc-2c(COCc3nnc(C4CCN(CC4)c4ccccn4)n-23)c1
Structure
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