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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Vasopressin V1a receptor | ||
| Ligand | BDBM50354907 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_772742 (CHEMBL1837354) | ||
| IC50 | 199±n/a nM | ||
| Citation |  Johnson, PS; Ryckmans, T; Bryans, J; Beal, DM; Dack, KN; Feeder, N; Harrison, A; Lewis, M; Mason, HJ; Mills, J; Newman, J; Pasquinet, C; Rawson, DJ; Roberts, LR; Russell, R; Spark, D; Stobie, A; Underwood, TJ; Ward, R; Wheeler, S Discovery of PF-184563, a potent and selective V1a antagonist for the treatment of dysmenorrhoea. The influence of compound flexibility on microsomal stability. Bioorg Med Chem Lett21:5684-7 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Vasopressin V1a receptor | |||
| Name: | Vasopressin V1a receptor | ||
| Synonyms: | AVPR V1a | AVPR1 | AVPR1A | Antidiuretic hormone receptor 1a | V1AR_HUMAN | V1aR | VASOPRESSIN V1A | Vascular/hepatic-type arginine vasopressin receptor | Vasopressin V1 receptor | Vasopressin V1a receptor | Vasopressin receptor | ||
| Type: | Receptor | ||
| Mol. Mass.: | 46820.18 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P37288 | ||
| Residue: | 418 | ||
| Sequence: |
| ||
| BDBM50354907 | |||
| n/a | |||
| Name | BDBM50354907 | ||
| Synonyms: | CHEMBL1837013 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H23N5 | ||
| Mol. Mass. | 333.4301 | ||
| SMILES | Cc1nnc(C2CCN(CC2)c2ccccn2)n1-c1ccccc1C |(20.94,-16.85,;19.48,-16.37,;19,-14.91,;17.46,-14.91,;16.99,-16.37,;15.66,-17.15,;14.32,-16.39,;12.99,-17.17,;13.01,-18.71,;14.36,-19.47,;15.68,-18.69,;11.68,-19.49,;10.34,-18.73,;9.01,-19.52,;9.03,-21.06,;10.38,-21.82,;11.7,-21.03,;18.23,-17.27,;18.23,-18.81,;16.89,-19.58,;16.89,-21.12,;18.23,-21.89,;19.57,-21.12,;19.56,-19.58,;20.89,-18.8,)| | ||
| Structure | 
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