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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50354984 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_772056 (CHEMBL1837665) | ||
| Ki | 7±n/a nM | ||
| Citation |  Miller, DC; Klute, W; Brown, AD Discovery of potent, metabolically stable purine CRF-1 antagonists with differentiated binding kinetic profiles. Bioorg Med Chem Lett21:6108-11 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
| ||
| BDBM50354984 | |||
| n/a | |||
| Name | BDBM50354984 | ||
| Synonyms: | CHEMBL1836948 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H22F3N5O | ||
| Mol. Mass. | 417.4275 | ||
| SMILES | Cc1nc2c(NC(C3CC3)C3CC3)nc(C)nc2n1-c1ccc(OC(F)F)cc1F |(42.35,-43.62,;40.81,-43.62,;39.9,-42.36,;38.42,-42.84,;37.09,-42.08,;37.08,-40.54,;35.75,-39.77,;35.74,-38.23,;36.51,-36.91,;34.97,-36.91,;34.42,-40.55,;32.88,-40.55,;33.65,-41.88,;35.76,-42.85,;35.76,-44.39,;34.42,-45.16,;37.09,-45.16,;38.42,-44.39,;39.9,-44.87,;40.69,-46.19,;39.94,-47.53,;40.73,-48.85,;42.27,-48.83,;43.06,-50.15,;42.32,-51.49,;43.11,-52.81,;40.78,-51.52,;43.02,-47.47,;42.22,-46.16,;42.97,-44.81,)| | ||
| Structure | 
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