| Reaction Details |
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 | Report a problem with these data |
| Target | Cystine/glutamate transporter |
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| Ligand | BDBM50355007 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_772170 (CHEMBL1838227) |
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| IC50 | 75000±n/a nM |
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| Citation |  Shukla, K; Thomas, AG; Ferraris, DV; Hin, N; Sattler, R; Alt, J; Rojas, C; Slusher, BS; Tsukamoto, T Inhibition of xc¿?¿ transporter-mediated cystine uptake by sulfasalazine analogs. Bioorg Med Chem Lett21:6184-7 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cystine/glutamate transporter |
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| Name: | Cystine/glutamate transporter |
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| Synonyms: | SLC7A11 | XCT_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 55437.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_772170 |
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| Residue: | 501 |
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| Sequence: | MVRKPVVSTISKGGYLQGNVNGRLPSLGNKEPPGQEKVQLKRKVTLLRGVSIIIGTIIGA
GIFISPKGVLQNTGSVGMSLTIWTVCGVLSLFGALSYAELGTTIKKSGGHYTYILEVFGP
LPAFVRVWVELLIIRPAATAVISLAFGRYILEPFFIQCEIPELAIKLITAVGITVVMVLN
SMSVSWSARIQIFLTFCKLTAILIIIVPGVMQLIKGQTQNFKDAFSGRDSSITRLPLAFY
YGMYAYAGWFYLNFVTEEVENPEKTIPLAICISMAIVTIGYVLTNVAYFTTINAEELLLS
NAVAVTFSERLLGNFSLAVPIFVALSCFGSMNGGVFAVSRLFYVASREGHLPEILSMIHV
RKHTPLPAVIVLHPLTMIMLFSGDLDSLLNFLSFARWLFIGLAVAGLIYLRYKCPDMHRP
FKVPLFIPALFSFTCLFMVALSLYSDPFSTGIGFVITLTGVPAYYLFIIWDKKPRWFRIM
SEKITRTLQIILEVVPEEDKL
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| BDBM50355007 |
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| n/a |
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| Name | BDBM50355007 |
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| Synonyms: | CHEMBL1834959 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H14N2O4S |
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| Mol. Mass. | 378.401 |
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| SMILES | OC(=O)c1cccc(c1)C#Cc1ccc(cc1)S(=O)(=O)Nc1ccccn1 |
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| Structure | 
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