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TargetBradykinin B1 receptor
LigandBDBM50355063
Substrate/Competitorn/a
Meas. Tech.ChEMBL_772771
IC50 1.1±n/a nM
Citation Biswas KPeterkin TABryan MCArik LLehto SGSun HHsieh FYXu CFremeau RTAllen JR Discovery of potent, orally bioavailable phthalazinone bradykinin B1 receptor antagonists. J Med Chem 54:7232-46 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Bradykinin B1 receptor
Name:Bradykinin B1 receptor
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:39519.62
Organism:Oryctolagus cuniculus
Description:ChEMBL_796432
Residue:352
Sequence:
MASQGPLELQPSNQSQLAPPNATSCSGAPDAWDLLHRLLPTFIIAIFTLGLLGNSFVLSV
FLLARRRLSVAEIYLANLAASDLVFVLGLPFWAENVRNQFDWPFGAALCRIVNGVIKANL
FISIFLVVAISQDRYSVLVHPMASRRGRRRRQAQATCALIWLAGGLLSTPTFVLRSVRAV
PELNVSACILLLPHEAWHWLRMVELNLLGFLLPLAAILFFNCHILASLRRRGERVPSRCG
GPRDSKSTALILTLVASFLVCWAPYHFFAFLECLWQVHAIGGCFWEEFTDLGLQLSNFSA
FVNSCLNPVIYVFVGRLFRTKVWELCQQCSPRSLAPVSSSRRKEMLWGFWRN
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  Blast E-value cutoff:
BDBM50355063
n/a
NameBDBM50355063
Synonyms:CHEMBL1834619
TypeSmall organic molecule
Emp. Form.C31H32ClN5O2
Mol. Mass.542.071
SMILESCc1nn(-c2ccc(cn2)C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc23)c(=O)c2c(Cl)cccc12 |r|
Structure
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