Ki Summary

Reaction Details

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Target

Kallikrein-7

Ligand

BDBM50355088

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_772793 (CHEMBL1837532)

37200±n/a nM

Citation

Teixeira, TS; Freitas, RF; Abrahão, O; Devienne, KF; de Souza, LR; Blaber, SI; Blaber, M; Kondo, MY; Juliano, MA; Juliano, L; Puzer, L Biological evaluation and docking studies of natural isocoumarins as inhibitors for human kallikrein 5 and 7. Bioorg Med Chem Lett21:6112-5 (2011) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Kallikrein-7

Name:

Kallikrein-7

Synonyms:

Type:

PROTEIN

Mol. Mass.:

27535.05

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1469257

Residue:

253

Sequence:

MARSLLLPLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLV
NERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNS
QARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVY
KDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCK
FTKWINDTMKKHR

BDBM50355088

n/a

Name

BDBM50355088

Synonyms:

CHEMBL1834754

Type

Small organic molecule

Emp. Form.

C30H26O10

Mol. Mass.

546.5214

SMILES

COc1cc2cc3C[C@@H](C)OC(=O)c3c(O)c2c(O)c1-c1c(OC)cc2cc3C[C@@H](C)OC(=O)c3c(O)c2c1O |r,wU:8.8,29.32,(38.37,-41.46,;38.37,-39.92,;37.04,-39.15,;35.7,-39.92,;34.37,-39.14,;33.04,-39.92,;31.71,-39.15,;30.37,-39.93,;29.04,-39.15,;27.7,-39.92,;29.04,-37.6,;30.38,-36.84,;30.38,-35.3,;31.71,-37.61,;33.04,-36.83,;33.04,-35.29,;34.37,-37.6,;35.7,-36.84,;35.7,-35.3,;37.03,-37.6,;38.36,-36.83,;38.36,-35.28,;37.03,-34.51,;37.03,-32.97,;39.7,-34.51,;41.03,-35.28,;42.35,-34.51,;43.69,-35.27,;45.02,-34.5,;46.36,-35.28,;47.7,-34.51,;46.36,-36.82,;45.02,-37.59,;45.01,-39.13,;43.69,-36.82,;42.36,-37.6,;42.36,-39.14,;41.02,-36.82,;39.7,-37.59,;39.7,-39.13,)|

Structure