Reaction Details | |||
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Target | Diacylglycerol O-acyltransferase 1 | ||
Ligand | BDBM50355143 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_772695 (CHEMBL1837163) | ||
IC50 | 265±n/a nM | ||
Citation | Dow, RL; Andrews, M; Aspnes, GE; Balan, G; Michael Gibbs, E; Guzman-Perez, A; Karki, K; Laperle, JL; Li, JC; Litchfield, J; Munchhof, MJ; Perreault, C; Patel, L Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3-d]pyrimidine core. Bioorg Med Chem Lett21:6122-5 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Diacylglycerol O-acyltransferase 1 | |||
Name: | Diacylglycerol O-acyltransferase 1 | ||
Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
Type: | Protein | ||
Mol. Mass.: | 55297.82 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O75907 | ||
Residue: | 488 | ||
Sequence: |
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BDBM50355143 | |||
n/a | |||
Name | BDBM50355143 | ||
Synonyms: | CHEMBL1835920 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H28N4O3 | ||
Mol. Mass. | 396.4827 | ||
SMILES | CC1(C)Oc2ncnc(N)c2NC1c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1 |r,wU:19.21,wD:22.25,(32.7,-2.92,;31.16,-2.92,;31.93,-4.25,;29.82,-3.7,;28.47,-2.93,;27.14,-3.7,;25.8,-2.93,;25.8,-1.38,;27.13,-.61,;27.13,.93,;28.47,-1.38,;29.8,-.59,;31.15,-1.37,;32.48,-.6,;33.82,-1.36,;35.14,-.58,;35.13,.97,;33.78,1.72,;32.46,.93,;36.45,1.75,;36.42,3.28,;37.76,4.07,;39.1,3.31,;40.43,4.09,;41.77,3.33,;41.78,1.79,;43.09,4.12,;39.11,1.77,;37.79,.99,)| | ||
Structure |