Reaction Details | |||
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Target | Diacylglycerol O-acyltransferase 1 | ||
Ligand | BDBM50355144 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_772695 (CHEMBL1837163) | ||
IC50 | 10±n/a nM | ||
Citation | Dow, RL; Andrews, M; Aspnes, GE; Balan, G; Michael Gibbs, E; Guzman-Perez, A; Karki, K; Laperle, JL; Li, JC; Litchfield, J; Munchhof, MJ; Perreault, C; Patel, L Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3-d]pyrimidine core. Bioorg Med Chem Lett21:6122-5 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Diacylglycerol O-acyltransferase 1 | |||
Name: | Diacylglycerol O-acyltransferase 1 | ||
Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
Type: | Protein | ||
Mol. Mass.: | 55297.82 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O75907 | ||
Residue: | 488 | ||
Sequence: |
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BDBM50355144 | |||
n/a | |||
Name | BDBM50355144 | ||
Synonyms: | CHEMBL1834554 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H23N3O4 | ||
Mol. Mass. | 369.4143 | ||
SMILES | Nc1ncnc2OC[C@@H](Oc12)c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1 |r,wU:17.19,8.12,wD:20.23,(-9.01,-11.21,;-9,-12.75,;-10.33,-13.52,;-10.33,-15.06,;-9,-15.83,;-7.66,-15.07,;-6.32,-15.83,;-4.98,-15.05,;-4.98,-13.5,;-6.33,-12.72,;-7.67,-13.51,;-3.65,-12.74,;-2.32,-13.49,;-.99,-12.71,;-1.01,-11.17,;-2.36,-10.41,;-3.68,-11.2,;.31,-10.39,;.29,-8.85,;1.62,-8.07,;2.96,-8.82,;4.29,-8.04,;5.63,-8.8,;5.64,-10.34,;6.96,-8.02,;2.98,-10.36,;1.66,-11.14,)| | ||
Structure |