Reaction Details | |||
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Target | Diacylglycerol O-acyltransferase 1 | ||
Ligand | BDBM50355148 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_772695 (CHEMBL1837163) | ||
IC50 | 225±n/a nM | ||
Citation | Dow, RL; Andrews, M; Aspnes, GE; Balan, G; Michael Gibbs, E; Guzman-Perez, A; Karki, K; Laperle, JL; Li, JC; Litchfield, J; Munchhof, MJ; Perreault, C; Patel, L Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3-d]pyrimidine core. Bioorg Med Chem Lett21:6122-5 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Diacylglycerol O-acyltransferase 1 | |||
Name: | Diacylglycerol O-acyltransferase 1 | ||
Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
Type: | Protein | ||
Mol. Mass.: | 55297.82 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O75907 | ||
Residue: | 488 | ||
Sequence: |
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BDBM50355148 | |||
n/a | |||
Name | BDBM50355148 | ||
Synonyms: | CHEMBL1834557 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H25N5O3 | ||
Mol. Mass. | 407.4656 | ||
SMILES | Cc1noc(C[C@H]2CC[C@@H](CC2)c2ccc(cc2)[C@H]2COc3ncnc(N)c3O2)n1 |r,wU:18.19,9.12,wD:6.5,(23.76,-21.99,;22.81,-20.78,;23.24,-19.3,;21.96,-18.43,;20.75,-19.39,;19.41,-18.63,;18.08,-19.42,;16.74,-18.66,;15.41,-19.44,;15.43,-20.98,;16.78,-21.74,;18.1,-20.96,;14.11,-21.76,;14.13,-23.3,;12.8,-24.09,;11.47,-23.33,;11.44,-21.79,;12.76,-21.01,;10.14,-24.09,;10.14,-25.64,;8.8,-26.43,;7.46,-25.66,;6.12,-26.43,;4.79,-25.66,;4.79,-24.11,;6.12,-23.34,;6.11,-21.8,;7.45,-24.1,;8.79,-23.32,;21.28,-20.83,)| | ||
Structure |