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TargetDiacylglycerol O-acyltransferase 1
LigandBDBM50355148
Substrate/Competitorn/a
Meas. Tech.ChEMBL_772695 (CHEMBL1837163)
IC50 225±n/a nM
Citation Dow, RLAndrews, MAspnes, GEBalan, GMichael Gibbs, EGuzman-Perez, AKarki, KLaperle, JLLi, JCLitchfield, JMunchhof, MJPerreault, CPatel, L Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3-d]pyrimidine core. Bioorg Med Chem Lett21:6122-5 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Diacylglycerol O-acyltransferase 1
Name:Diacylglycerol O-acyltransferase 1
Synonyms:ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:Protein
Mol. Mass.:55297.82
Organism:Homo sapiens (Human)
Description:O75907
Residue:488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA
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  Blast E-value cutoff:
BDBM50355148
n/a
NameBDBM50355148
Synonyms:CHEMBL1834557
TypeSmall organic molecule
Emp. Form.C22H25N5O3
Mol. Mass.407.4656
SMILESCc1noc(C[C@H]2CC[C@@H](CC2)c2ccc(cc2)[C@H]2COc3ncnc(N)c3O2)n1 |r,wU:18.19,9.12,wD:6.5,(23.76,-21.99,;22.81,-20.78,;23.24,-19.3,;21.96,-18.43,;20.75,-19.39,;19.41,-18.63,;18.08,-19.42,;16.74,-18.66,;15.41,-19.44,;15.43,-20.98,;16.78,-21.74,;18.1,-20.96,;14.11,-21.76,;14.13,-23.3,;12.8,-24.09,;11.47,-23.33,;11.44,-21.79,;12.76,-21.01,;10.14,-24.09,;10.14,-25.64,;8.8,-26.43,;7.46,-25.66,;6.12,-26.43,;4.79,-25.66,;4.79,-24.11,;6.12,-23.34,;6.11,-21.8,;7.45,-24.1,;8.79,-23.32,;21.28,-20.83,)|
Structure
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