Reaction Details | |||
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Target | Diacylglycerol O-acyltransferase 1 | ||
Ligand | BDBM50355149 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_772696 (CHEMBL1837164) | ||
IC50 | 735±n/a nM | ||
Citation | Dow, RL; Andrews, M; Aspnes, GE; Balan, G; Michael Gibbs, E; Guzman-Perez, A; Karki, K; Laperle, JL; Li, JC; Litchfield, J; Munchhof, MJ; Perreault, C; Patel, L Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3-d]pyrimidine core. Bioorg Med Chem Lett21:6122-5 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Diacylglycerol O-acyltransferase 1 | |||
Name: | Diacylglycerol O-acyltransferase 1 | ||
Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
Type: | Protein | ||
Mol. Mass.: | 55297.82 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O75907 | ||
Residue: | 488 | ||
Sequence: |
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BDBM50355149 | |||
n/a | |||
Name | BDBM50355149 | ||
Synonyms: | CHEMBL1834558 | ||
Type | Small organic molecule | ||
Emp. Form. | C21H25N3O4 | ||
Mol. Mass. | 383.4409 | ||
SMILES | CC1(COc2ncnc(N)c2O1)c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1 |r,wU:18.20,wD:21.24,(33.4,-24.14,;32.31,-23.06,;32.32,-24.61,;30.97,-25.39,;29.63,-24.62,;28.3,-25.39,;26.96,-24.62,;26.96,-23.08,;28.29,-22.31,;28.29,-20.77,;29.63,-23.07,;30.96,-22.28,;33.64,-22.29,;34.98,-23.05,;36.3,-22.27,;36.29,-20.73,;34.93,-19.97,;33.62,-20.76,;37.61,-19.95,;37.58,-18.41,;38.91,-17.62,;40.26,-18.38,;41.58,-17.6,;42.93,-18.36,;42.94,-19.9,;44.25,-17.58,;40.27,-19.92,;38.95,-20.7,)| | ||
Structure |