| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily E member 1 |
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| Ligand | BDBM50355405 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_773768 (CHEMBL1840134) |
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| IC50 | >10000±n/a nM |
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| Citation |  Lim, J; Taoka, B; Otte, RD; Spencer, K; Dinsmore, CJ; Altman, MD; Chan, G; Rosenstein, C; Sharma, S; Su, HP; Szewczak, AA; Xu, L; Yin, H; Zugay-Murphy, J; Marshall, CG; Young, JR Discovery of 1-amino-5H-pyrido[4,3-b]indol-4-carboxamide inhibitors of Janus kinase 2 (JAK2) for the treatment of myeloproliferative disorders. J Med Chem54:7334-49 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium voltage-gated channel subfamily E member 1 |
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| Name: | Potassium voltage-gated channel subfamily E member 1 |
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| Synonyms: | Delayed rectifier potassium channel subunit IsK | IKs producing slow voltage-gated potassium channel subunit beta Mink | KCNE1 | KCNE1_HUMAN | KCNQ1(Kv7.1)/KCNE1(MinK) | Minimal potassium channel | Voltage-gated potassium channel beta subunit Mink | Voltage-gated potassium channel, IKs |
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| Type: | PROTEIN |
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| Mol. Mass.: | 14676.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1456351 |
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| Residue: | 129 |
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| Sequence: | MILSNTTAVTPFLTKLWQETVQQGGNMSGLARRSPRSSDGKLEALYVLMVLGFFGFFTLG
IMLSYIRSKKLEHSNDPFNVYIESDAWQEKDKAYVQARVLESYRSCYVVENHLAIEQPNT
HLPETKPSP
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| BDBM50355405 |
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| n/a |
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| Name | BDBM50355405 |
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| Synonyms: | CHEMBL1835153 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18F3N7O |
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| Mol. Mass. | 441.4091 |
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| SMILES | NC(=O)c1cnc(N[C@H](C2CC2)C(F)(F)F)c2c3ccc(cc3[nH]c12)-c1cnc(N)nc1 |r| |
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| Structure | 
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