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TargetVoltage-gated potassium channel beta subunit Mink
LigandBDBM50355405
Substrate/Competitorn/a
Meas. Tech.ChEMBL_773768
IC50>10000±n/a nM
Citation Lim JTaoka BOtte RDSpencer KDinsmore CJAltman MDChan GRosenstein CSharma SSu HPSzewczak AAXu LYin HZugay-Murphy JMarshall CGYoung JR Discovery of 1-amino-5H-pyrido[4,3-b]indol-4-carboxamide inhibitors of Janus kinase 2 (JAK2) for the treatment of myeloproliferative disorders. J Med Chem 54:7334-49 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Voltage-gated potassium channel beta subunit Mink
Name:Voltage-gated potassium channel beta subunit Mink
Synonyms:Delayed rectifier potassium channel subunit IsK | IKs producing slow voltage-gated potassium channel subunit beta Mink | KCNQ1(Kv7.1)/KCNE1(MinK) | Minimal potassium channel | Voltage-gated potassium channel, IKs
Type:PROTEIN
Mol. Mass.:14676.11
Organism:Homo sapiens (Human)
Description:ChEMBL_1456351
Residue:129
Sequence:
MILSNTTAVTPFLTKLWQETVQQGGNMSGLARRSPRSSDGKLEALYVLMVLGFFGFFTLG
IMLSYIRSKKLEHSNDPFNVYIESDAWQEKDKAYVQARVLESYRSCYVVENHLAIEQPNT
HLPETKPSP
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  Blast E-value cutoff:
BDBM50355405
n/a
NameBDBM50355405
Synonyms:CHEMBL1835153
TypeSmall organic molecule
Emp. Form.C21H18F3N7O
Mol. Mass.441.4091
SMILESNC(=O)c1cnc(N[C@H](C2CC2)C(F)(F)F)c2c3ccc(cc3[nH]c12)-c1cnc(N)nc1 |r|
Structure
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