| Reaction Details |
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 | Report a problem with these data |
| Target | Hormonally up-regulated neu tumor-associated kinase |
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| Ligand | BDBM50326053 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_774564 (CHEMBL1908781) |
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| Kd | 240±n/a nM |
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| Citation |  Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol29:1046-51 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hormonally up-regulated neu tumor-associated kinase |
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| Name: | Hormonally up-regulated neu tumor-associated kinase |
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| Synonyms: | B19 | HUNK | HUNK_HUMAN | MAKV | Serine/threonine-protein kinase MAK-V |
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| Type: | PROTEIN |
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| Mol. Mass.: | 79715.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774564 |
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| Residue: | 714 |
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| Sequence: | MPAAAGDGLLGEPAAPGGGGGAEDAARPAAACEGSFLPAWVSGVPRERLRDFQHHKRVGN
YLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRH
PNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRA
GVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKY
GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSL
LEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVLHMTEKLGYKNS
DVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTRLYQIEKYRAPKESYEA
SLDTWTRDLEFHAVQDKKPKEQEKRGDFLHRPFSKKLDKNLPSHKQPSGSLMTQIQNTKA
LLKDRKASKSSFPDKDSFGCRNIFRKTSDSNCVASSSMEFIPVPPPRTPRIVKKPEPHQP
GPGSTGIPHKEDPLMLDMVRSFESVDRDDHVEVLSPSHHYRILNSPVSLARRNSSERTLS
PGLPSGSMSPLHTPLHPTLVSFAHEDKNSPPKEEGLCCPPPVPSNGPMQPLGSPNCVKSR
GRFPMMGIGQMLRKRHQSLQPSADRPLEASLPPLQPLAPVNLAFDMADGVKTQC
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| BDBM50326053 |
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| n/a |
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| Name | BDBM50326053 |
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| Synonyms: | CHEMBL608533 | PKC-412 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H30N4O4 |
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| Mol. Mass. | 570.6371 |
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| SMILES | CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 |r| |
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| Structure | 
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